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Scientists working in a biotechnology laboratory

Research

Primary literature, not slogans

Every scientific claim we make should be checkable. This bibliography lists independently indexed papers and patents by PHP Biotech scientists and advisors — with DOI, PMID, or patent number.

PHP Biotech’s foundational peptide work is described in Bezerra and Motti, Molecules (2024): “3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line” (doi:10.3390/molecules29071646, PMID 38611925). The company’s bioactive-peptide family is disclosed in PCT publication WO2023220553.

Author pages include education, affiliations, ORCID where available, and sameAs links to PubMed, ResearchGate, and institutional profiles. We list only records we can independently verify. Unpublished internal data is not presented as peer-reviewed work.

Company bibliography

Indexed on PubMed, Crossref, or Google Patents. Internal, unpublished data is not listed as peer-reviewed work.

  1. Commentary · 2025

    Should We Be Paying Clinical Research Participants? A Global Perspective

    Motti EF

    Clinical Leader (guest column)

    Industry commentary, 4 March 2025.

  2. Peer-reviewed · 2024

    3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line

    Bezerra P, Motti EF

    Molecules. 2024;29(7):1646

    doi:10.3390/molecules29071646PMID 38611925

    Peer-reviewed open access. Authors affiliated with PHP Biotech International Inc.; research funded by the company.

  3. Commentary · 2024

    Is Clinical Research Inclusive Or Extractive?

    Motti EF

    Clinical Leader (guest column)

    Industry commentary on trial inclusivity, 6 December 2024.

  4. Peer-reviewed · 2024

    Antitumor effects of co-treatment of resveratrol with antitumor drugs in ER- and HER2-positive breast cancer cells are due to induction of apoptosis and modulation of estrogen receptor expression

    Franceschi BT, Bezerra PHA, Torqueti MR

    Breast Cancer. 2024

    doi:10.1007/s12282-024-01590-6PMID 38780752

  5. Peer-reviewed · 2023

    In Vitro Effects of Combining Genistein with Aromatase Inhibitors: Concerns Regarding Its Consumption during Breast Cancer Treatment

    Bezerra PHA, Amaral C, Almeida CF, Correia-da-Silva G, Torqueti MR, Teixeira N

    Molecules. 2023;28(13):4893

    doi:10.3390/molecules28134893PMID 37446555

    First author. Work from USP / University of Porto collaboration.

  6. Patent · 2023

    Bioactive peptides, compositions, production process, and use of bioactive peptides as anti-tumor agents

    Bighetti MR, Bezerra PHA

    WO2023220553A2 (PCT/US2023/066685); applicant PHP Biotech International Inc.

    Named inventor. Non-toxic bioactive snake-venom peptide for aggressive solid tumors.

  7. Peer-reviewed · 2022

    Soybean extract modified by Aspergillus awamori stimulates a greater collagen-I synthesis in the intracellular matrix of human fibroblasts

    Bezerra PHA et al.

    J Cosmet Dermatol. 2022;21(3):1243-1250

    doi:10.1111/jocd.14208PMID 33969632

    First author. Indexed against ORCID 0000-0001-7860-3002.

  8. Peer-reviewed · 2019

    BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation

    Bezerra PHA, Ferreira IM, Franceschi BT, Bianchini F, Ambrosio L, Cintra ACO, Sampaio SV, Castro FA, Torqueti MR

    J Venom Anim Toxins Incl Trop Dis. 2019;25:e20190010

    doi:10.1590/1678-9199-JVATITD-2019-0010PMID 31384244

    First author. Open access (PMC6665320).

  9. Peer-reviewed · 2017

    Pulmonary Sarcomatoid Carcinomas Commonly Harbor Either Potentially Targetable Genomic Alterations or High Tumor Mutational Burden as Observed by Comprehensive Genomic Profiling

    Schrock AB, Li SD, Frampton GM, Suh J, Braun E, et al.

    J Thorac Oncol. 2017;12(6):932-942

    doi:10.1016/j.jtho.2017.03.005PMID 28315738

    Co-author. Indexed on PubMed; ~194 citations (Google Scholar / PubMed citing articles).

  10. Review · 2017

    Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual

    Gershenwald JE, Scolyer RA, Hess KR, et al. (includes Buzaid AC)

    CA Cancer J Clin. 2017;67(6):472-492

    doi:10.3322/caac.21409PMID 29028110

    AJCC eighth-edition melanoma staging. ~2,900 citations.

  11. Review · 2014

    Algorithm for the management of metastatic cutaneous melanoma

    Buzaid AC, Agarwala SS, Hauschild A, Atkins M

    Chin Clin Oncol. 2014;3(3):32

    doi:10.3978/j.issn.2304-3865.2014.07.01PMID 25841458

    First author of the review.

  12. Peer-reviewed · 2009

    Final version of 2009 AJCC melanoma staging and classification

    Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, et al.

    J Clin Oncol. 2009;27(36):6199-6206

    doi:10.1200/JCO.2009.23.4799PMID 19917835

    Co-author. Open access (PMC2793035). ~6,000 citations.

  13. Book · 2002

    Manual de Oncologia Clínica do Brasil (Brazilian Manual of Clinical Oncology)

    Buzaid AC (co-editor since 2002)

    10th edition; Spanish and English translations; >45,000 copies

    National reference textbook for clinical oncology in Brazil.

  14. Peer-reviewed · 2002

    Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial

    Eton O, Legha SS, Bedikian AY, Buzaid AC, et al.

    J Clin Oncol. 2002;20(8):2045-2052

    doi:10.1200/JCO.2002.07.044PMID 11956264

    Co-author. Phase III. ~475 citations.

  15. Peer-reviewed · 2001

    Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma

    Balch CM, Buzaid AC, Soong SJ, et al.

    J Clin Oncol. 2001;19(16):3635-3648

    doi:10.1200/JCO.2001.19.16.3635PMID 11504745

    Second author. AJCC melanoma staging revision. ~3,400 citations.

  16. Peer-reviewed · 1997

    Critical analysis of the current American Joint Committee on Cancer staging system for cutaneous melanoma and proposal of a new staging system

    Buzaid AC, Ross MI, Balch CM, et al.

    J Clin Oncol. 1997;15(3):1039-1051

    doi:10.1200/JCO.1997.15.3.1039PMID 9060544

    First author. Landmark critique that informed subsequent AJCC melanoma staging. ~418 citations.

Authors and inventors

See also the full team and preclinical science.