
Research
Primary literature, not slogans
Every scientific claim we make should be checkable. This bibliography lists independently indexed papers and patents by PHP Biotech scientists and advisors — with DOI, PMID, or patent number.
PHP Biotech’s foundational peptide work is described in Bezerra and Motti, Molecules (2024): “3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line” (doi:10.3390/molecules29071646, PMID 38611925). The company’s bioactive-peptide family is disclosed in PCT publication WO2023220553.
Author pages include education, affiliations, ORCID where available, and sameAs links to PubMed, ResearchGate, and institutional profiles. We list only records we can independently verify. Unpublished internal data is not presented as peer-reviewed work.
Company bibliography
Indexed on PubMed, Crossref, or Google Patents. Internal, unpublished data is not listed as peer-reviewed work.
Commentary · 2025
Should We Be Paying Clinical Research Participants? A Global Perspective
Motti EF
Clinical Leader (guest column)
Industry commentary, 4 March 2025.
Peer-reviewed · 2024
3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line
Bezerra P, Motti EF
Molecules. 2024;29(7):1646
doi:10.3390/molecules29071646PMID 38611925
Peer-reviewed open access. Authors affiliated with PHP Biotech International Inc.; research funded by the company.
Commentary · 2024
Is Clinical Research Inclusive Or Extractive?
Motti EF
Clinical Leader (guest column)
Industry commentary on trial inclusivity, 6 December 2024.
Peer-reviewed · 2024
Antitumor effects of co-treatment of resveratrol with antitumor drugs in ER- and HER2-positive breast cancer cells are due to induction of apoptosis and modulation of estrogen receptor expression
Franceschi BT, Bezerra PHA, Torqueti MR
Breast Cancer. 2024
Peer-reviewed · 2023
In Vitro Effects of Combining Genistein with Aromatase Inhibitors: Concerns Regarding Its Consumption during Breast Cancer Treatment
Bezerra PHA, Amaral C, Almeida CF, Correia-da-Silva G, Torqueti MR, Teixeira N
Molecules. 2023;28(13):4893
doi:10.3390/molecules28134893PMID 37446555
First author. Work from USP / University of Porto collaboration.
Patent · 2023
Bioactive peptides, compositions, production process, and use of bioactive peptides as anti-tumor agents
Bighetti MR, Bezerra PHA
WO2023220553A2 (PCT/US2023/066685); applicant PHP Biotech International Inc.
Named inventor. Non-toxic bioactive snake-venom peptide for aggressive solid tumors.
Peer-reviewed · 2022
Soybean extract modified by Aspergillus awamori stimulates a greater collagen-I synthesis in the intracellular matrix of human fibroblasts
Bezerra PHA et al.
J Cosmet Dermatol. 2022;21(3):1243-1250
doi:10.1111/jocd.14208PMID 33969632
First author. Indexed against ORCID 0000-0001-7860-3002.
Peer-reviewed · 2019
BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation
Bezerra PHA, Ferreira IM, Franceschi BT, Bianchini F, Ambrosio L, Cintra ACO, Sampaio SV, Castro FA, Torqueti MR
J Venom Anim Toxins Incl Trop Dis. 2019;25:e20190010
doi:10.1590/1678-9199-JVATITD-2019-0010PMID 31384244
First author. Open access (PMC6665320).
Peer-reviewed · 2017
Pulmonary Sarcomatoid Carcinomas Commonly Harbor Either Potentially Targetable Genomic Alterations or High Tumor Mutational Burden as Observed by Comprehensive Genomic Profiling
Schrock AB, Li SD, Frampton GM, Suh J, Braun E, et al.
J Thorac Oncol. 2017;12(6):932-942
doi:10.1016/j.jtho.2017.03.005PMID 28315738
Co-author. Indexed on PubMed; ~194 citations (Google Scholar / PubMed citing articles).
Review · 2017
Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual
Gershenwald JE, Scolyer RA, Hess KR, et al. (includes Buzaid AC)
CA Cancer J Clin. 2017;67(6):472-492
doi:10.3322/caac.21409PMID 29028110
AJCC eighth-edition melanoma staging. ~2,900 citations.
Review · 2014
Algorithm for the management of metastatic cutaneous melanoma
Buzaid AC, Agarwala SS, Hauschild A, Atkins M
Chin Clin Oncol. 2014;3(3):32
doi:10.3978/j.issn.2304-3865.2014.07.01PMID 25841458
First author of the review.
Peer-reviewed · 2009
Final version of 2009 AJCC melanoma staging and classification
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, et al.
J Clin Oncol. 2009;27(36):6199-6206
doi:10.1200/JCO.2009.23.4799PMID 19917835
Co-author. Open access (PMC2793035). ~6,000 citations.
Book · 2002
Manual de Oncologia Clínica do Brasil (Brazilian Manual of Clinical Oncology)
Buzaid AC (co-editor since 2002)
10th edition; Spanish and English translations; >45,000 copies
National reference textbook for clinical oncology in Brazil.
Peer-reviewed · 2002
Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial
Eton O, Legha SS, Bedikian AY, Buzaid AC, et al.
J Clin Oncol. 2002;20(8):2045-2052
doi:10.1200/JCO.2002.07.044PMID 11956264
Co-author. Phase III. ~475 citations.
Peer-reviewed · 2001
Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma
Balch CM, Buzaid AC, Soong SJ, et al.
J Clin Oncol. 2001;19(16):3635-3648
doi:10.1200/JCO.2001.19.16.3635PMID 11504745
Second author. AJCC melanoma staging revision. ~3,400 citations.
Peer-reviewed · 1997
Critical analysis of the current American Joint Committee on Cancer staging system for cutaneous melanoma and proposal of a new staging system
Buzaid AC, Ross MI, Balch CM, et al.
J Clin Oncol. 1997;15(3):1039-1051
doi:10.1200/JCO.1997.15.3.1039PMID 9060544
First author. Landmark critique that informed subsequent AJCC melanoma staging. ~418 citations.
Authors and inventors
- Eduardo Motti, MDChief Operating Officer3 listed publications
- Patrícia Bezerra, PhDHead of Research & Development5 listed publications · 1 patent · ORCID 0000-0001-7860-3002
- Moacyr BighettiFounder & Executive Committee1 patent
- Eduardo Braun, MDExecutive Committee Member1 listed publication
- Antonio Carlos Buzaid, MDAdvisory Board Member7 listed publications
See also the full team and preclinical science.